PDF DatasheetHuman SMUG1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SMUG1 based upon sequence from: Human
Isoform: Isoform 2
Host: QP7679 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SMUG1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7679.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Leu177
Amino Acid Sequence: MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE HPKRPVLGLE CPQSEGPRQS MGHEIKSELL MGGCSWIRGK IQCDRVQVRR PGFSSQL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human SMUG1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SMUG1 Protein General Information | |
|---|---|
| Alternate Names | |
| FDG; UNG3; HMUDG; Single-strand selective monofunctional uracil DNA glycosyla | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SMUG1 |
| Entrez Gene ID | 23583 |
| Ensemble Gene ID | ENSG00000123415 |
| RefSeq Protein Accession(s) | NP_001230716.1 |
| RefSeq mRNA Accession(s) | NM_001243787.1, NM_001243788.1, NM_001243789.1, NM_001243790.1, NM_001243791.1, NM_014311.2, XM_006719319.3, XM_006719320.3, XM_006719321.3, XM_006719322.3, XM_011538109.2, XM_011538110.2, XM_011538111.2, XM_011538112.2, XM_011538113.2, XM_011538114.2, XM_011538115.2, XM_011538116.2, XM_011538117.2, XM_011538118.2, XM_011538119.2, XM_011538120.2, XM_011538121.2, XM_011538122.2, XM_017019113.1, XM_017019114.1, XM_017019115.1, XM_017019116.1, XM_017019117.1, XM_017019118.1, XM_017019119.1, XM_017019120.1 |
| UniProt ID(s) | Q53HV7 |
| UniGene ID(s) | Hs.632721 |
| HGNC ID(s) | HGNC:17148 |
| COSMIC ID Link(s) | SMUG1 |
| KEGG Gene ID(s) | hsa:23583 |
| PharmGKB ID(s) | PA142670895 |
| General Description of Recombinant Human SMUG1 Protein. | |
| Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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