PDF DatasheetMouse Tyrosine-protein kinase JAK3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Tyrosine-protein kinase JAK3 based upon sequence from: Mouse
Host: QP7690 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Tyrosine-protein kinase JAK3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7690.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu818 – Gly1100
Amino Acid Sequence: LKYISLLGKG NFGSVELCRY DPLGDNTGPL VAVKQLQHSG PDQQRDFQRE IQILKALHSD FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL HTDRLLLFAW QICKGMEYLG ARRCVHRDLA ARNILVESEA HVKIADFGLA KLLPLGKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW SFGVVLYELF TYCDKSCSPS AEFLRMMGPE REGPPLCRLL ELLAEGRRLP PPPTCPTEVQ ELMQLCWAPS PHDRPAFGTL SPQLDALWRG RPG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Tyrosine-protein kinase JAK3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Tyrosine-protein kinase JAK3 Protein General Information | |
|---|---|
| Alternate Names | |
| fae; wil | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Jak3 |
| Entrez Gene ID | 16453 |
| RefSeq Protein Accession(s) | NP_001177759.1 |
| RefSeq mRNA Accession(s) | NM_001190830.1, NM_010589.6 |
| UniProt ID(s) | Q62137 |
| UniGene ID(s) | Mm.249645 |
| COSMIC ID Link(s) | Jak3 |
| KEGG Gene ID(s) | mmu:16453 |
| General Description of Recombinant Mouse Tyrosine-protein kinase JAK3 Protein. | |
| Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hatopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the Cytoplasmic domain tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their Cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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