PDF DatasheetEpstein-Barr Epstein-Barr nuclear antigen 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Epstein-Barr nuclear antigen 2 based upon sequence from: Epstein-Barr
Host: QP7694 protein expressed in E.coli, Yeast..
Tag: His-B2M
Protein Construction: A DNA sequence encoding the Epstein-Barr virus Epstein-Barr nuclear antigen 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7694.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser247 – Gln454
Amino Acid Sequence: SYSIPSMTLS PEPLPPPAAP AHPLPGVIYD QQALPPTPGP PWWPPVRDPT PTTQTPPTNT KQGPDQGQGR GRWRGRGRSK GRGRMHKLPE PRRPGPDTSS PSMPQLSPVV SLHQGQGPEN SPTPGPSTAG PVCRVTPSAT PDISPIHEPE SSDSEEPPFL FPSDWYPPTL EPAELDESWE GIFETTESHS SDEENVGGPS KRPRTSTQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Epstein-Barr Epstein-Barr nuclear antigen 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Epstein-Barr Epstein-Barr nuclear antigen 2 Protein General Information | |
|---|---|
| Alternate Names | |
| HHV4tp2_gp06 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EBNA2 |
| Entrez Gene ID | 5176198 |
| RefSeq Protein Accession(s) | YP_001129441.1 |
| RefSeq mRNA Accession(s) | NC_009334.1 |
| UniProt ID(s) | Q69022 |
| KEGG Gene ID(s) | vg:5176198 |
| General Description of Recombinant Epstein-Barr Epstein-Barr nuclear antigen 2 Protein. | |
| Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-associated transcription factors TFIIB, TAF40, TFIIH components ERCC2 and ERCC3, and CBP in order to promote transcription. Alternatively, EBNA2 can affect activities of cell cycle regulators and retard cell cycle progression at G2/M phase. It also induces chromosomal instability, by disrupting mitotic checkpoints, multi-nucleation and formation of micronuclei in infected cells (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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