PDF DatasheetHuman PDZK1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PDZK1 based upon sequence from: Human
Host: QP7705 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PDZK1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7705.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Met519
Amino Acid Sequence: MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ DGDRVLRING VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAVKTRV DLKELGQSQK EQGLSDNILS PVMNGGVQTW TQPRLCYLVK EGGSYGFSLK TVQGKKGVYM TDITPQGVAM RAGVLADDHL IEVNGENVED ASHEEVVEKV KKSGSRVMFL LVDKETDKRH VEQKIQFKRE TASLKLLPHQ PRIVEMKKGS NGYGFYLRAG SEQKGQIIKD IDSGSPAEEA GLKNNDLVVA VNGESVETLD HDSVVEMIRK GGDQTSLLVV DKETDNMYRL AHFSPFLYYQ SQELPNGSVK EAPAPTPTSL EVSSPPDTTE EVDHKPKLCR LAKGENGYGF HLNAIRGLPG SFIKEVQKGG PADLAGLEDE DVIIEVNGVN VLDEPYEKVV DRIQSSGKNV TLLVCGKKAY DYFQAKKIPI VSSLADPLDT PPDSKEGIVV ESNHDSHMAK ERAHSTASHS SSNSEDTEM
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PDZK1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PDZK1 Protein General Information | |
|---|---|
| Alternate Names | |
| PDZD1; CAP70; CLAMP; NHERF3; NHERF-3; Na(+)/H(+) exchange regulatory cofactor NHE-R | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PDZK1 |
| Entrez Gene ID | 5174 |
| Ensemble Gene ID | ENSG00000174827 |
| RefSeq Protein Accession(s) | NP_001188254.1 |
| RefSeq mRNA Accession(s) | NM_001201325.1, NM_001201326.1, NM_002614.4, XM_017001464.1 |
| UniProt ID(s) | Q5T2W1 |
| UniGene ID(s) | Hs.444751 |
| HGNC ID(s) | HGNC:8821 |
| COSMIC ID Link(s) | PDZK1 |
| KEGG Gene ID(s) | hsa:5174 |
| PharmGKB ID(s) | PA33165 |
| General Description of Recombinant Human PDZK1 Protein. | |
| A scaffold protein that connects plasma mbrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated mbrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma mbrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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