PDF DatasheetHuman Meteorin-like protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Meteorin-like protein based upon sequence from: Human
Host: QP7719 protein expressed in E.coli, Yeast, Mammal..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Meteorin-like protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7719.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gln46 – Asp311
Amino Acid Sequence: QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS GANIYLEKTG ELRLLVPDGD GRPGRVQCFG LEQGGLFVEA TPQQDIGRRT TGFQYELVRR HRASDLHELS APCRPCSDTE VLLAVCTSDF AVRGSIQQVT HEPERQDSAI HLRVSRLYRQ KSRVFEPVPE GDGHWQGRVR TLLECGVRPG HGDFLFTGHM HFGEARLGCA PRFKDFQRMY RDAQERGLNP CEVGTD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Meteorin-like protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Meteorin-like protein Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | METRNL |
| Entrez Gene ID | 284207 |
| Ensemble Gene ID | ENSG00000176845 |
| RefSeq Protein Accession(s) | NP_001004431.1 |
| RefSeq mRNA Accession(s) | NM_001004431.2, XM_017024523.1 |
| UniProt ID(s) | Q641Q3 |
| UniGene ID(s) | Hs.378821 |
| HGNC ID(s) | HGNC:27584 |
| COSMIC ID Link(s) | METRNL |
| KEGG Gene ID(s) | hsa:284207 |
| PharmGKB ID(s) | PA134970048 |
| General Description of Recombinant Human Meteorin-like protein Protein. | |
| Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold tperatures . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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