PDF DatasheetHuman EIF3M Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant EIF3M based upon sequence from: Human
Host: QP7743 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) EIF3M, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7743.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 – Thr374
Amino Acid Sequence: SVPAFIDISE EDQAAELRAY LKSKGAEISE ENSEGGLHVD LAQIIEACDV CLKEDDKDVE SVMNSVVSLL LILEPDKQEA LIESLCEKLV KFREGERPSL RLQLLSNLFH GMDKNTPVRY TVYCSLIKVA ASCGAIQYIP TELDQVRKWI SDWNLTTEKK HTLLRLLYEA LVDCKKSDAA SKVMVELLGS YTEDNASQAR VDAHRCIVRA LKDPNAFLFD HLLTLKPVKF LEGELIHDLL TIFVSAKLAS YVKFYQNNKD FIDSLGLLHE QNMAKMRLLT FMGMAVENKE ISFDTMQQEL QIGADDVEAF VIDAVRTKMV YCKIDQTQRK VVVSHSTHRT FGKQQWQQLY DTLNAWKQNL NKVKNSLLSL SDT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human EIF3M Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human EIF3M Protein General Information | |
|---|---|
| Alternate Names | |
| TANGO7; PCID1; hfl-B5; B5; GA17; Eukaryotic translation initiation factor 3 subunit | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EIF3M |
| Entrez Gene ID | 10480 |
| Ensemble Gene ID | ENSG00000149100 |
| RefSeq Protein Accession(s) | NP_001294858.1 |
| RefSeq mRNA Accession(s) | NM_001307929.1, NM_006360.5 |
| UniProt ID(s) | Q7L2H7 |
| UniGene ID(s) | Hs.502244 |
| HGNC ID(s) | HGNC:24460 |
| COSMIC ID Link(s) | EIF3M |
| KEGG Gene ID(s) | hsa:10480 |
| PharmGKB ID(s) | PA162384944 |
| General Description of Recombinant Human EIF3M Protein. | |
| Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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