PDF DatasheetHuman RRM2B / P53R2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant RRM2B / P53R2 based upon sequence from: Human
Host: QP7745 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RRM2B / P53R2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7745.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MGDPERPEAA GLDQDERSSS DTNESEIKSN EEPLLRKSSR RFVIFPIQYP DIWKMYKQAQ ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD GIVNENLVER FSQEVQVPEA RCFYGFQILI ENVHSEMYSL LIDTYIRDPK KREFLFNAIE TMPYVKKKAD WALRWIADRK STFGERVVAF AAVEGVFFSG SFAAIFWLKK RGLMPGLTFS NELISRDEGL HCDFACLMFQ YLVNKPSEER VREIIVDAVK IEQEFLTEAL PVGLIGMNCI LMKQYIEFVA DRLLVELGFS KVFQAENPFD FMENISLEGK TNFFEKRVSE YQRFAVMAET TDNVFTLDAD F
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human RRM2B / P53R2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human RRM2B / P53R2 Protein General Information | |
|---|---|
| Alternate Names | |
| RRM2B; P53R2; MTDPS8A; P53R2; MTDPS8B | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RRM2B |
| Entrez Gene ID | 50484 |
| Ensemble Gene ID | ENSG00000048392 |
| RefSeq Protein Accession(s) | NP_001165948.1 |
| RefSeq mRNA Accession(s) | NM_001172477.1, NM_001172478.1, NM_015713.4 |
| UniProt ID(s) | Q7LG56 |
| UniGene ID(s) | Hs.512592 |
| HGNC ID(s) | HGNC:17296 |
| COSMIC ID Link(s) | RRM2B |
| KEGG Gene ID(s) | hsa:50484 |
| PharmGKB ID(s) | PA34866 |
| General Description of Recombinant Human RRM2B / P53R2 Protein. | |
| Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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