PDF DatasheetHuman Histone H2A.V Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Histone H2A.V based upon sequence from: Human
Host: QP7750 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Histone H2A.V, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7750.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ala128
Amino Acid Sequence: MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG KKGQQKTA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Histone H2A.V Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Histone H2A.V Protein General Information | |
|---|---|
| Alternate Names | |
| H2A.Z-2; H2AV | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | H2AFV |
| Entrez Gene ID | 94239 |
| Ensemble Gene ID | ENSG00000105968 |
| RefSeq Protein Accession(s) | NP_036544.1 |
| RefSeq mRNA Accession(s) | NM_012412.4, NM_138635.3, NM_201436.2, NM_201516.2, NM_201517.2 |
| UniProt ID(s) | Q71UI9 |
| UniGene ID(s) | Hs.488189 |
| HGNC ID(s) | HGNC:20664 |
| COSMIC ID Link(s) | H2AFV |
| KEGG Gene ID(s) | hsa:94239 |
| PharmGKB ID(s) | PA134895050 |
| General Description of Recombinant Human Histone H2A.V Protein. | |
| Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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