PDF DatasheetHuman COP9 signalosome complex subunit 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant COP9 signalosome complex subunit 2 based upon sequence from: Human
Host: QP7761 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) COP9 signalosome complex subunit 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7761.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ala443
Amino Acid Sequence: MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human COP9 signalosome complex subunit 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human COP9 signalosome complex subunit 2 Protein General Information | |
|---|---|
| Alternate Names | |
| ALIEN; CSN2; TRIP15; SGN2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COPS2 |
| Entrez Gene ID | 9318 |
| Ensemble Gene ID | ENSG00000166200 |
| RefSeq Protein Accession(s) | NP_001137359.1 |
| RefSeq mRNA Accession(s) | NM_001143887.1, NM_004236.3 |
| UniProt ID(s) | P61201 |
| UniGene ID(s) | Hs.369614 |
| HGNC ID(s) | HGNC:30747 |
| COSMIC ID Link(s) | COPS2 |
| KEGG Gene ID(s) | hsa:9318 |
| PharmGKB ID(s) | PA134952445 |
| General Description of Recombinant Human COP9 signalosome complex subunit 2 Protein. | |
| Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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