PDF DatasheetHuman CREB3L2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CREB3L2 based upon sequence from: Human
Host: QP7764 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CREB3L2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7764.
Bioactivity Data: Untested
Full Length? Full Length of BC063666
Amino Acid Sequence: MEVLESGEQG VLQWDRKLSE LSEPGDGEAL MYHTHFSELL DEFSQNVLGQ LLNDPFLSEK SVSMEVEPSP TSPAPLIQAE HSYSLCEEPR AQSPFTHITS DSFNDDEVES EKWYLSTDFP STSIKTEPVT DEPPPGLVPS VTLTITAIST PLEKEEPPLE MNTGVDSSCQ TIIPKIKLEP HEVDQFLNFS PKEGLSALPV SLWVMDMVSG STEREYGERA GMSLYHRCCS WLYEIALFLK NKNFASK
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CREB3L2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CREB3L2 Protein General Information | |
|---|---|
| Alternate Names | |
| BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CREB3L2 |
| Entrez Gene ID | 64764 |
| Ensemble Gene ID | ENSG00000182158 |
| RefSeq Protein Accession(s) | NP_001240704.1 |
| RefSeq mRNA Accession(s) | NM_001253775.1, NM_194071.3 |
| UniProt ID(s) | Q70SY1 |
| UniGene ID(s) | Hs.490273 |
| HGNC ID(s) | HGNC:23720 |
| COSMIC ID Link(s) | CREB3L2 |
| KEGG Gene ID(s) | hsa:64764 |
| PharmGKB ID(s) | PA134914841 |
| General Description of Recombinant Human CREB3L2 Protein. | |
| Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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