PDF DatasheetHuman Ragulator complex protein LAMTOR1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ragulator complex protein LAMTOR1 based upon sequence from: Human
Host: QP7766 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ragulator complex protein LAMTOR1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7766.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Pro161
Amino Acid Sequence: MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ragulator complex protein LAMTOR1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ragulator complex protein LAMTOR1 Protein General Information | |
|---|---|
| Alternate Names | |
| Ragulator1; PDRO; C11orf59; p18; p27RF-Rho | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LAMTOR1 |
| Entrez Gene ID | 55004 |
| Ensemble Gene ID | ENSG00000149357 |
| RefSeq Protein Accession(s) | NP_060377.1 |
| RefSeq mRNA Accession(s) | NM_017907.2 |
| UniProt ID(s) | Q6IAA8 |
| UniGene ID(s) | Hs.731528 |
| HGNC ID(s) | HGNC:26068 |
| COSMIC ID Link(s) | LAMTOR1 |
| KEGG Gene ID(s) | hsa:55004 |
| PharmGKB ID(s) | PA143485354 |
| General Description of Recombinant Human Ragulator complex protein LAMTOR1 Protein. | |
| As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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