PDF DatasheetHuman PLCZ1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PLCZ1 based upon sequence from: Human
Host: QP7781 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PLCZ1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7781.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ser415
Amino Acid Sequence: MEMRWFLSKI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV KQIFKDNDRL KQGRITIEEF RAIYRIITHR EEIIEIFNTY SENRKILLAS NLAQFLTQEQ YAAEMSKAIA FEIIQKYEPI EEVRKAHQMS LEGFTRYMDS RECLLFKNEC RKVYQDMTHP LNDYFISSSH NTYLVSDQLL GPSDLWGYVS ALVKGCRCLE IDCWDGAQNE PVVYHGYTLT SKLLFKTVIQ AIHKYAFMTS DYPVVLSLEN HCSTAQQEVM ADNLQATFGE SLLSDMLDDF PDTLPSPEAL KFKILVKNKK IGTLKETHER KGSDKRGDNQ DKETGVKKLP GVMLFKKKKT RKLKIALALS DLVIYTKAEK FKSFQHSRLY QQFNENNSIG ETQARKLSKL RVHEFIFHTR KFITRIYPKA TRADS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PLCZ1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PLCZ1 Protein General Information | |
|---|---|
| Alternate Names | |
| SPGF17; NYD-SP27; PLC-zeta-1; PLCzeta; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PLCZ1 |
| Entrez Gene ID | 89869 |
| Ensemble Gene ID | ENSG00000139151 |
| RefSeq Protein Accession(s) | NP_001317698.1 |
| RefSeq mRNA Accession(s) | NM_001330769.1, NM_001330774.1, NM_033123.3 |
| UniProt ID(s) | Q86YW0 |
| UniGene ID(s) | Hs.743832 |
| HGNC ID(s) | HGNC:19218 |
| COSMIC ID Link(s) | PLCZ1 |
| KEGG Gene ID(s) | hsa:89869 |
| PharmGKB ID(s) | PA134875646 |
| General Description of Recombinant Human PLCZ1 Protein. | |
| The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating bryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete mbrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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