PDF DatasheetHuman TIR domain-containing adapter molecule 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TIR domain-containing adapter molecule 2 based upon sequence from: Human
Host: QP7797 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TIR domain-containing adapter molecule 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7797.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly1 – Ala235
Amino Acid Sequence: GIGKSKINSC PLSLSWGKRH SVDTSPGYHE SDSKKSEDLS LCNVAEHSNT TEGPTGKQEG AQSVEEMFEE EAEEEVFLKF VILHAEDDTD EALRVQNLLQ DDFGIKPGII FAEMPCGRQH LQNLDDAVNG SAWTILLLTE NFLRDTWCNF QFYTSLMNSV NRQHKYNSVI PMRPLNNPLP RERTPFALQT INALEEESRG FPTQVERIFQ ESVYKTQQTI WKETRNMVQR QFIA
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TIR domain-containing adapter molecule 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TIR domain-containing adapter molecule 2 Protein General Information | |
|---|---|
| Alternate Names | |
| TRAM; TIRAP3; TICAM-2; MyD88-4; TIRP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TICAM2 |
| Entrez Gene ID | 100302736 |
| Ensemble Gene ID | ENSG00000243414 |
| RefSeq Protein Accession(s) | NP_001157940.1 |
| RefSeq mRNA Accession(s) | NM_001164468.3, NM_001164469.3, NM_021649.7 |
| UniProt ID(s) | Q86XR7 |
| UniGene ID(s) | Hs.718838 |
| HGNC ID(s) | HGNC:21354 |
| COSMIC ID Link(s) | TICAM2 |
| KEGG Gene ID(s) | hsa:100302736 |
| PharmGKB ID(s) | PA134881157 |
| General Description of Recombinant Human TIR domain-containing adapter molecule 2 Protein. | |
| Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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