PDF DatasheetHuman m7GpppN-mRNA hydrolase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant m7GpppN-mRNA hydrolase based upon sequence from: Human
Isoform: Isoform 2
Host: QP7809 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) m7GpppN-mRNA hydrolase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7809.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Leu385
Amino Acid Sequence: METKRVEIPG SVLDDFCSRF ILHIPSEERD NAIRVCFQIE LAHWFYLDFY MQNTPGLPQC GIRDFAKAVF SHCPFLLPQG EDVEKVLDEW KEYKMGVPTY GAIILDETLE NVLLVQGYLA KSGWGFPKGK VNKEEAPHDC AAREVFEETG FDIKDYICKD DYIELRINDQ LARLYIIPGI PKDTKFNPKT RREIRNIEWF SIEKLPCHRN DMTPKSKLGL APNKFFMAIP FIRPLRDWLS RRFGDSSDSD NGFSSTGSTP AKPTVEKLSR TKFRHSQQLF PDGSPGDQWV KHRQPLQQKP YNNHSEMSDL LKGKKCEKKL HPRKLQDNFE TDAVYDLPSS SEDQLLEHAE GQPVACNGHC KFPFSSRAFL SFKFDHNAIM KILDL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human m7GpppN-mRNA hydrolase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human m7GpppN-mRNA hydrolase Protein General Information | |
|---|---|
| Alternate Names | |
| NUDT20 | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DCP2 |
| Entrez Gene ID | 167227 |
| Ensemble Gene ID | ENSG00000172795 |
| RefSeq Protein Accession(s) | NP_001229306.1 |
| RefSeq mRNA Accession(s) | NM_001242377.1, NM_152624.5 |
| UniProt ID(s) | Q8IU60 |
| UniGene ID(s) | Hs.443875 |
| HGNC ID(s) | HGNC:24452 |
| COSMIC ID Link(s) | DCP2 |
| KEGG Gene ID(s) | hsa:167227 |
| PharmGKB ID(s) | PA134898646 |
| General Description of Recombinant Human m7GpppN-mRNA hydrolase Protein. | |
| Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Roves the 7-methyl guanine cap structure from mRNA molecules, yielding a 5′-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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