PDF DatasheetHuman COMM domain-containing protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant COMM domain-containing protein 1 based upon sequence from: Human
Host: QP7824 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) COMM domain-containing protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7824.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala1 – Asn190
Amino Acid Sequence: AAGELEGGKP LSGLLNALAQ DTFHGYPGIT EELLRSQLYP EVPPEEFRPF LAKMRGILKS IASADMDFNQ LEAFLTAQTK KQGGITSDQA AVISKFWKSH KTKIRESLMN QSRWNSGLRG LSWRVDGKSQ SRHSAQIHTP VAIIELELGK YGQESEFLCL EFDEVKVNQI LKTLSEVEES ISTLISQPN
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human COMM domain-containing protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human COMM domain-containing protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| MURR1; C2orf5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | COMMD1 |
| Entrez Gene ID | 150684 |
| Ensemble Gene ID | ENSG00000173163 |
| RefSeq Protein Accession(s) | NP_689729.1 |
| RefSeq mRNA Accession(s) | NM_152516.3 |
| UniProt ID(s) | Q8N668 |
| UniGene ID(s) | Hs.468702 |
| HGNC ID(s) | HGNC:23024 |
| COSMIC ID Link(s) | COMMD1 |
| KEGG Gene ID(s) | hsa:150684 |
| PharmGKB ID(s) | PA134891368 |
| General Description of Recombinant Human COMM domain-containing protein 1 Protein. | |
| Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes . Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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