PDF DatasheetHuman Apoptosis-enhancing nuclease Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Apoptosis-enhancing nuclease based upon sequence from: Human
Host: QP7830 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Apoptosis-enhancing nuclease, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7830.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met117 – Asn325
Amino Acid Sequence: MVGTGPRGRV SELARCSIVS YHGNVLYDKY IRPEMPIADY RTRWSGITRQ HMRKAVPFQV AQKEILKLLK GKVVVGHALH NDFQALKYVH PRSQTRDTTY VPNFLSEPGL HTRARVSLKD LALQLLHKKI QVGQHGHSSV EDATTAMELY RLVEVQWEQQ EARSLWTCPE DREPDSSTDM EQYMEDQYWP DDLAHGSRGG AREAQDRRN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Apoptosis-enhancing nuclease Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Apoptosis-enhancing nuclease Protein General Information | |
|---|---|
| Alternate Names | |
| ISG20L1; pp12744 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AEN |
| Entrez Gene ID | 64782 |
| Ensemble Gene ID | ENSG00000181026 |
| RefSeq Protein Accession(s) | NP_073604.3 |
| RefSeq mRNA Accession(s) | NM_022767.3, XM_005254966.1, XM_005254967.1, XM_011521905.2, XM_017022489.1 |
| UniProt ID(s) | Q8WTP8 |
| UniGene ID(s) | Hs.436102 |
| HGNC ID(s) | HGNC:25722 |
| COSMIC ID Link(s) | AEN |
| KEGG Gene ID(s) | hsa:64782 |
| PharmGKB ID(s) | PA162375720 |
| General Description of Recombinant Human Apoptosis-enhancing nuclease Protein. | |
| Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancent of apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.