PDF DatasheetHuman PTPMT1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PTPMT1 based upon sequence from: Human
Host: QP7832 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PTPMT1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7832.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Lys28 – Thr201
Amino Acid Sequence: KVPGRAHRDW YHRIDPTVLL GALPLRSLTR QLVQDENVRG VITMNEEYET RFLCNSSQEW KRLGVEQLRL STVDMTGIPT LDNLQKGVQF ALKYQSLGQC VYVHCKAGRS RSATMVAAYL IQVHKWSPEE AVRAIAKIRS YIHIRPGQLD VLKEFHKQIT ARATKDGTFV ISKT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PTPMT1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PTPMT1 Protein General Information | |
|---|---|
| Alternate Names | |
| DUSP23; MOSP; PNAS-129; PLIP; Phosphatidylglycerophosphatase and protein-tyrosine phosphatase | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTPMT1 |
| Entrez Gene ID | 114971 |
| Ensemble Gene ID | ENSG00000110536 |
| RefSeq Protein Accession(s) | NP_001137456.1 |
| RefSeq mRNA Accession(s) | NM_001143984.1, NM_175732.2 |
| UniProt ID(s) | Q8WUK0 |
| UniGene ID(s) | Hs.656205 |
| HGNC ID(s) | HGNC:26965 |
| COSMIC ID Link(s) | PTPMT1 |
| KEGG Gene ID(s) | hsa:114971 |
| PharmGKB ID(s) | PA142671115 |
| General Description of Recombinant Human PTPMT1 Protein. | |
| Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the mbrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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