PDF DatasheetHuman Dystonin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Dystonin based upon sequence from: Human
Host: QP7837 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Dystonin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7837.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Pro195
Amino Acid Sequence: MAGYLSPAAY LYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG IRCENFTTCW RDGKLFNAII HKYRP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Dystonin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Dystonin Protein General Information | |
|---|---|
| Alternate Names | |
| CATX-15; MACF2; BPAG1; BP240; BPA; HSAN6; CATX15; D6S1101; DMH; DT; EBSB2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DST |
| Entrez Gene ID | 667 |
| Ensemble Gene ID | ENSG00000151914 |
| RefSeq Protein Accession(s) | NP_001138241.1 |
| RefSeq mRNA Accession(s) | NM_001144769.2, NM_001144770.1, NM_001723.5, NM_015548.4, NM_183380.3, XM_017011224.1 |
| UniProt ID(s) | Q03001 |
| UniGene ID(s) | Hs.604915 |
| HGNC ID(s) | HGNC:1090 |
| COSMIC ID Link(s) | DST |
| KEGG Gene ID(s) | hsa:667 |
| PharmGKB ID(s) | PA25399 |
| General Description of Recombinant Human Dystonin Protein. | |
| Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus.By similarity3 Publications Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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