PDF DatasheetHuman SWI / SNF complex subunit SMARCC1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SWI / SNF complex subunit SMARCC1 based upon sequence from: Human
Host: QP7840 protein expressed in Baculovirus, E.coli..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SWI/SNF complex subunit SMARCC1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7840.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ile449 – Pro669
Amino Acid Sequence: IIIPSYASWF DYNCIHVIER RALPEFFNGK NKSKTPEIYL AYRNFMIDTY RLNPQEYLTS TACRRNLTGD VCAVMRVHAF LEQWGLVNYQ VDPESRPMAM GPPPTPHFNV LADTPSGLVP LHLRSPQVPA AQQMLNFPEK NKEKPVDLQN FGLRTDIYSK KTLAKSKGAS AGREWTEQET LLLLEALEMY KDDWNKVSEH VGSRTQDECI LHFLRLPIED P
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human SWI / SNF complex subunit SMARCC1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SWI / SNF complex subunit SMARCC1 Protein General Information | |
|---|---|
| Alternate Names | |
| BAF155; Rsc8; CRACC1; SWI3; SRG3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SMARCC1 |
| Entrez Gene ID | 6599 |
| Ensemble Gene ID | ENSG00000173473 |
| RefSeq Protein Accession(s) | NP_003065.3 |
| RefSeq mRNA Accession(s) | NM_003074.3 |
| UniProt ID(s) | Q92922 |
| UniGene ID(s) | Hs.476179 |
| HGNC ID(s) | HGNC:11104 |
| COSMIC ID Link(s) | SMARCC1 |
| KEGG Gene ID(s) | hsa:6599 |
| PharmGKB ID(s) | PA35954 |
| General Description of Recombinant Human SWI / SNF complex subunit SMARCC1 Protein. | |
| Involved in transcriptional activation and repression of select genes by chromatin rodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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