PDF DatasheetHuman PDK / PDZ binding kinase / TOPK Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PDK / PDZ binding kinase / TOPK based upon sequence from: Human
Host: QP7845 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PDK / PDZ binding kinase / TOPK, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7845.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MEGISNFKTP SKLSEKKKSV LCSTPTINIP ASPFMQKLGF GTGVNVYLMK RSPRGLSHSP WAVKKINPIC NDHYRSVYQK RLMDEAKILK SLHHPNIVGY RAFTEANDGS LCLAMEYGGE KSLNDLIEER YKASQDPFPA AIILKVALNM ARGLKYLHQE KKLLHGDIKS SNVVIKGDFE TIKICDVGVS LPLDENMTVT DPEACYIGTE PWKPKEAVEE NGVITDKADI FAFGLTLWEM MTLSIPHINL SNDDDDEDKT FDESDFDDEA YYAALGTRPP INMEELDESY QKVIELFSVC TNEDPKDRPS AAHIVEALET DV
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PDK / PDZ binding kinase / TOPK Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PDK / PDZ binding kinase / TOPK Protein General Information | |
|---|---|
| Alternate Names | |
| PDK; PDZ binding kinase; TOPK; SPK; HEL164; Nori-3; CT84; TOPK | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PBK |
| Entrez Gene ID | 55872 |
| Ensemble Gene ID | ENSG00000168078 |
| RefSeq Protein Accession(s) | NP_001265874.1 |
| RefSeq mRNA Accession(s) | NM_001278945.1, NM_018492.3, XM_006716368.2 |
| UniProt ID(s) | Q96KB5 |
| UniGene ID(s) | Hs.104741 |
| HGNC ID(s) | HGNC:18282 |
| COSMIC ID Link(s) | PBK |
| KEGG Gene ID(s) | hsa:55872 |
| PharmGKB ID(s) | PA134925802 |
| General Description of Recombinant Human PDK / PDZ binding kinase / TOPK Protein. | |
| Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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