PDF DatasheetHuman IL-22R / IL22RA1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant IL-22R / IL22RA1 based upon sequence from: Human
Host: QP7852 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IL-22R / IL22RA1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7852.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser250 – Glu573
Amino Acid Sequence: SYRYVTKPPA PPNSLNVQRV LTFQPLRFIQ EHVLIPVFDL SGPSSLAQPV QYSQIRVSGP REPAGAPQRH SLSEITYLGQ PDISILQPSN VPPPQILSPL SYAPNAAPEV GPPSYAPQVT PEAQFPFYAP QAISKVQPSS YAPQATPDSW PPSYGVCMEG SGKDSPTGTL SSPKHLRPKG QLQKEPPAGS CMLGGLSLQE VTSLAMEESQ EAKSLHQPLG ICTDRTSDPN VLHSGEEGTP QYLKGQLPLL SSVQIEGHPM SLPLQPPSRP CSPSDQGPSP WGLLESLVCP KDEAKSPAPE TSDLEQPTEL DSLFRGLALT VQWE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL-22R / IL22RA1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-22R / IL22RA1 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-22R; IL22RA1; RGD1559655 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL22RA1 |
| Entrez Gene ID | 58985 |
| Ensemble Gene ID | ENSG00000142677 |
| RefSeq Protein Accession(s) | NP_067081.2 |
| RefSeq mRNA Accession(s) | NM_021258.3 |
| UniProt ID(s) | Q8N6P7 |
| UniGene ID(s) | Hs.110915 |
| HGNC ID(s) | HGNC:13700 |
| COSMIC ID Link(s) | IL22RA1 |
| KEGG Gene ID(s) | hsa:58985 |
| PharmGKB ID(s) | PA29823 |
| General Description of Recombinant Human IL-22R / IL22RA1 Protein. | |
| Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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