PDF DatasheetHuman Cyclic GMP-AMP synthase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cyclic GMP-AMP synthase based upon sequence from: Human
Host: QP7853 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cyclic GMP-AMP synthase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7853.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly161 – Phe522
Amino Acid Sequence: GASKLRAVLE KLKLSRDDIS TAAGMVKGVV DHLLLRLKCD SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE EYSNTRAYYF VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND IKDTDVIMKR KRGGSPAVTL LISEKISVDI TLALESKSSW PASTQEGLRI QNWLSAKVRK QLRLKPFYLV PKHAKEGNGF QEETWRLSFS HIEKEILNNH GKSKTCCENK EEKCCRKDCL KLMKYLLEQL KERFKDKKHL DKFSSYHVKT AFFHVCTQNP QDSQWDRKDL GLCFDNCVTY FLQCLRTEKL ENYFIPEFNL FSSNLIDKRS KEFLTKQIEY ERNNEFPVFD EF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Cyclic GMP-AMP synthase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Cyclic GMP-AMP synthase Protein General Information | |
|---|---|
| Alternate Names | |
| C6orf150; h-cGAS; cGAS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MB21D1 |
| Entrez Gene ID | 115004 |
| Ensemble Gene ID | ENSG00000164430 |
| RefSeq Protein Accession(s) | NP_612450.2 |
| RefSeq mRNA Accession(s) | NM_138441.2 |
| UniProt ID(s) | Q8N884 |
| UniGene ID(s) | Hs.658405 |
| HGNC ID(s) | HGNC:21367 |
| COSMIC ID Link(s) | MB21D1 |
| KEGG Gene ID(s) | hsa:115004 |
| PharmGKB ID(s) | PA134956015 |
| General Description of Recombinant Human Cyclic GMP-AMP synthase Protein. | |
| Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2′,5′ phosphodiester linkage at the GpA step and the formation of a 3′,5′ phosphodiester linkage at the ApG step, producing c[G(2′,5′)pA(3′,5′)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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