PDF DatasheetMouse Nlrp3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Nlrp3 based upon sequence from: Mouse
Host: QP7856 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Nlrp3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7856.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Arg153
Amino Acid Sequence: MTSVRCKLAQ YLEDLEDVDL KKFKMHLEDY PPEKGCIPVP RGQMEKADHL DLATLMIDFN GEEKAWAMAV WIFAAINRRD LWEKAKKDQP EWNDTCTSHS SMVCQEDSLE EEWMGLLGYL SRISICKKKK DYCKMYRRHV RSRFYSIKDR NAR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Nlrp3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Nlrp3 Protein General Information | |
|---|---|
| Alternate Names | |
| MWS; AGTAVPRL; Cias1; NALP3; AII/AVP; FCU; Mmig1; FCAS; Pypaf1; NACHT, LRR and PYD domains-containing protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Nlrp3 |
| Entrez Gene ID | 216799 |
| Ensemble Gene ID | ENSMUSG00000032691 |
| RefSeq Protein Accession(s) | NP_665826.1 |
| RefSeq mRNA Accession(s) | NM_145827.3, XM_006532857.1, XM_006532858.1 |
| UniProt ID(s) | Q8R4B8 |
| UniGene ID(s) | Mm.54174 |
| COSMIC ID Link(s) | Nlrp3 |
| KEGG Gene ID(s) | mmu:216799 |
| General Description of Recombinant Mouse Nlrp3 Protein. | |
| May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA (By similarity). Activates caspase-1 as part of the NALP3 inflammasome complex in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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