PDF DatasheetChinese Hamster P4HB / ERBA2L Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant P4HB / ERBA2L based upon sequence from: Chinese Hamster
Host: QP7857 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Chinese hamster P4HB / ERBA2L, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7857.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Asp20 – Leu509
Amino Acid Sequence: DAPEEEDNVL VLKKSNFAEA LAAHNYLLVE FYAPWCGHCK ALAPEYAKAA AKLKAEGSEI RLAKVDATEE SDLAQQYGVR GYPTIKFFKN GDTASPKEYT AGREADDIVN WLKKRTGPAA TTLSDTAAAE TLIDSSEVAV IGFFKDVESD SAKQFLLAAE AVDDIPFGIT SNSGVFSKYQ LDKDGVVLFK KFDEGRNNFE GEVTKEKLLD FIKHNQLPLV IEFTEQTAPK IFGGEIKTHI LLFLPKSVSD YDGKLGNFKK AAEGFKGKIL FIFIDSDHTD NQRILEFFGL KKEECPAVRL ITLEEEMTKY KPESDELTAE KITEFCHRFL EGKIKPHLMS QELPEDWDKQ PVKVLVGKNF EEVAFDEKKN VFVEFYAPWC GHCKQLAPIW DKLGETYKDH ENIIIAKMDS TANEVEAVKV HSFPTLKFFP ATADRTVIDY NGERTLDGFK KFLESGGQDG AGDDDDVDLE EALEPDMEED DDQKAVKDEL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Chinese Hamster P4HB / ERBA2L Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Chinese Hamster P4HB / ERBA2L Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | P4hb |
| Entrez Gene ID | 100689433 |
| RefSeq Protein Accession(s) | NP_001233622.1 |
| RefSeq mRNA Accession(s) | NM_001246693.1 |
| UniProt ID(s) | Q8R4U2 |
| COSMIC ID Link(s) | P4hb |
| KEGG Gene ID(s) | cge:100689433 |
| General Description of Recombinant Chinese Hamster P4HB / ERBA2L Protein. | |
| This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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