PDF DatasheetHuman Splicing factor U2AF 26 kDa subunit Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Splicing factor U2AF 26 kDa subunit based upon sequence from: Human
Isoform: Isoform 2
Host: QP7888 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Splicing factor U2AF 26 kDa subunit, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7888.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Met202
Amino Acid Sequence: MAEYLASIFG TEKDKVNCSF YFKIGVCRHG DRCSRLHNKP TFSQEVFTEL QEKYGEIEEM NVCDNLGDHL VGNVYVKFRR EEDGERAVAE LSNRWFNGQA VHGNVPEVAS ATSCICGPFP RTSRGSSMGG DPGAGHPRGS ILATIPERGT IGVPLITGMA ASEALAPLPF TPNRDRCSWQ DLSSKPPSLS CPILPRLPGS IM
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Splicing factor U2AF 26 kDa subunit Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Splicing factor U2AF 26 kDa subunit Protein General Information | |
|---|---|
| Alternate Names | |
| U2af26; U2AF1-RS3; U2AF1L3; U2AF1L3V1; U2AF1RS3 | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | U2AF1L4 |
| Entrez Gene ID | 199746 |
| Ensemble Gene ID | ENSG00000161265 |
| RefSeq Protein Accession(s) | NP_001035515.1 |
| RefSeq mRNA Accession(s) | NM_001040425.2, NM_144987.3 |
| UniProt ID(s) | Q8WU68 |
| UniGene ID(s) | Hs.351558 |
| HGNC ID(s) | HGNC:23020 |
| COSMIC ID Link(s) | U2AF1L4 |
| KEGG Gene ID(s) | hsa:199746 |
| PharmGKB ID(s) | PA164742763 |
| General Description of Recombinant Human Splicing factor U2AF 26 kDa subunit Protein. | |
| RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3′-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3′-splice site. Shows a preference for AGC or AGA | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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