PDF DatasheetHuman DCUN1D1 / SCCRO Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DCUN1D1 / SCCRO based upon sequence from: Human
Host: QP7895 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DCUN1D1 / SCCRO, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7895.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val259
Amino Acid Sequence: MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI DDFVEFARPQ IAGTKSTTV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human DCUN1D1 / SCCRO Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DCUN1D1 / SCCRO Protein General Information | |
|---|---|
| Alternate Names | |
| DCUN1D1; SCCRO; SCCRO; DCUN1L1; SCRO; DCNL1; Tes3; RP42 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DCUN1D1 |
| Entrez Gene ID | 54165 |
| Ensemble Gene ID | ENSG00000043093 |
| RefSeq Protein Accession(s) | NP_001295030.1 |
| RefSeq mRNA Accession(s) | NM_001308101.1, NM_020640.3 |
| UniProt ID(s) | Q96GG9 |
| UniGene ID(s) | Hs.592789 |
| HGNC ID(s) | HGNC:18184 |
| COSMIC ID Link(s) | DCUN1D1 |
| KEGG Gene ID(s) | hsa:54165 |
| PharmGKB ID(s) | PA142672008 |
| General Description of Recombinant Human DCUN1D1 / SCCRO Protein. | |
| Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates . Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assbly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression .1 Publication | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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