PDF DatasheetHuman Centrosomal protein of 63 kDa Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Centrosomal protein of 63 kDa based upon sequence from: Human
Isoform: Isoform 3
Host: QP7898 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Centrosomal protein of 63 kDa, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7898.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 3
Expression Region: Met1 – Lys495
Amino Acid Sequence: MEALLEGIQN RGHGGGFLTS CEAELQELMK QIDIMVAHKK SEWEGRTHAL ETCLKIREQE LKSLRSQLDV THKEVGMLHQ QVEEHEKIKQ EMTMEYKQEL KKLHEELCIL KRSYEKLQKK QMREFRGNTK NHREDRSEIE RLTAKIEEFR QKSLDWEKQR LIYQQQVSSL EAQRKALAEQ SEIIQAQLVN RKQKLESVEL SSQSEIQHLS SKLERANDTI CANELEIERL TMRVNDLVGT SMTVLQEQQQ KEEKLRESEK LLEALQEEKR ELKAALQSQE NLIHEARIQK EKLQEKVKAT NTQHAVEAIS LESVSATCKQ LSQELMEKYE ELKRMEAHNN EYKAEIKKLK EQILQGEQSY SSALEGMKME ISHLTQELHQ RDITIASTKG SSSDMEKRLR AEMQKAEDKA VEHKEILDQL ESLKLENRHL SEMVMKLELG LHECSLPVSP LGSIATRFLE EEELRSHHIL ERLDAHIEEL KRESEKTVRQ FTALK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Centrosomal protein of 63 kDa Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Centrosomal protein of 63 kDa Protein General Information | |
|---|---|
| Alternate Names | |
| SCKL6 | |
| Molecular Weight | |
| Isoform 3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CEP63 |
| Entrez Gene ID | 80254 |
| Ensemble Gene ID | ENSG00000182923 |
| RefSeq Protein Accession(s) | NP_001035842.1 |
| RefSeq mRNA Accession(s) | NM_001042383.1, NM_001042384.1, NM_001042400.1, NM_025180.3, XM_005247797.3, XM_006713760.3, XM_011513194.2, XM_017007254.1, XM_017007255.1, XM_017007256.1, XM_017007262.1, XM_017007263.1, XM_017007264.1, XM_017007266.1, XM_017007267.1 |
| UniProt ID(s) | Q96MT8 |
| UniGene ID(s) | Hs.443301 |
| HGNC ID(s) | HGNC:25815 |
| COSMIC ID Link(s) | CEP63 |
| KEGG Gene ID(s) | hsa:80254 |
| PharmGKB ID(s) | PA142672124 |
| General Description of Recombinant Human Centrosomal protein of 63 kDa Protein. | |
| Required for normal spindle assbly. Plays a key role in mother-centriole-dependent centriole duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is roved from centrosomes; this leads to the inactivation of spindle assbly and delay in mitotic progression. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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