PDF DatasheetHuman Bile acid receptor Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Bile acid receptor based upon sequence from: Human
Isoform: Isoform 3
Host: QP7899 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Bile acid receptor, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7899.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 3
Expression Region: Met1 – Thr476
Amino Acid Sequence: MVMQFQGLEN PIQISPHCSC TPSGFFMEMM SMKPAKGVLT EQVAGPLGQN LEVEPYSQYS NVQFPQVQPQ ISSSSYYSNL GFYPQQPEEW YSPGIYELRR MPAETLYQGE TEVAEMPVTK KPRMGASAGR IKGDELCVVC GDRASGYHYN ALTCEGCKGF FRRSITKNAV YKCKNGGNCV MDMYMRRKCQ ECRLRKCKEM GMLAECMYTG LLTEIQCKSK RLRKNVKQHA DQTVNEDSEG RDLRQVTSTT KSCREKTELT PDQQTLLHFI MDSYNKQRMP QEITNKILKE EFSAEENFLI LTEMATNHVQ VLVEFTKKLP GFQTLDHEDQ IALLKGSAVE AMFLRSAEIF NKKLPSGHSD LLEERIRNSG ISDEYITPMF SFYKSIGELK MTQEEYALLT AIVILSPDRQ YIKDREAVEK LQEPLLDVLQ KLCKIHQPEN PQHFACLLGR LTELRTFNHH HAEMLMSWRV NDHKFT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Bile acid receptor Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Bile acid receptor Protein General Information | |
|---|---|
| Alternate Names | |
| PFIC5; BAR; HRR1; FXR; HRR-1; RIP14 | |
| Molecular Weight | |
| Isoform 3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NR1H4 |
| Entrez Gene ID | 9971 |
| Ensemble Gene ID | ENSG00000012504 |
| RefSeq Protein Accession(s) | NP_001193906.1 |
| RefSeq mRNA Accession(s) | NM_001206977.1, NM_001206978.1, NM_001206979.1, NM_001206992.1, NM_001206993.1, NM_005123.3, XM_011539040.2 |
| UniProt ID(s) | Q96RI1 |
| UniGene ID(s) | Hs.282735 |
| HGNC ID(s) | HGNC:7967 |
| COSMIC ID Link(s) | NR1H4 |
| KEGG Gene ID(s) | hsa:9971 |
| PharmGKB ID(s) | PA31752 |
| General Description of Recombinant Human Bile acid receptor Protein. | |
| Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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