PDF DatasheetHuman NMNAT3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NMNAT3 based upon sequence from: Human
Isoform: Isoform 2
Host: QP7901 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NMNAT3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7901.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Ser215
Amino Acid Sequence: MYQVIQGIIS PVNDTYGKKD LAASHHRVAM ARLALQTSDW IRVDPWESEQ AQWMETVKVL RHHHSKLLRS PPQMEGPDHG KALFSTPAAV PELKLLCGAD VLKTFQTPNL WKDAHIQEIV EKFGLVCVGR VGHDPKGYIA ESPILRMHQH NIHLAKEPVQ NEISATYIRR ALGQGQSVKY LIPDAVITYI KDHGLYTKGS TWKGKSTQST EGKTS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NMNAT3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NMNAT3 Protein General Information | |
|---|---|
| Alternate Names | |
| PNAT-3; FKSG76; PNAT3; Nicotinamide/nicotinic acid mononucleotide adenylyltransferase | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NMNAT3 |
| Entrez Gene ID | 349565 |
| Ensemble Gene ID | ENSG00000163864 |
| RefSeq Protein Accession(s) | NP_001186976.1 |
| RefSeq mRNA Accession(s) | NM_001200047.2, NM_001320511.1, NM_001320512.1, NM_178177.4, XM_011512790.1, XM_011512791.2, XM_017006335.1, XM_017006336.1, XM_017006337.1, XM_017006338.1 |
| UniProt ID(s) | Q96T66 |
| UniGene ID(s) | Hs.208673 |
| HGNC ID(s) | HGNC:20989 |
| COSMIC ID Link(s) | NMNAT3 |
| KEGG Gene ID(s) | hsa:349565 |
| PharmGKB ID(s) | PA134952303 |
| General Description of Recombinant Human NMNAT3 Protein. | |
| Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, can use NAD+, NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+. Protects against axonal degeneration following injury. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.