PDF DatasheetHuman UFD1L, homolog Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant UFD1L, homolog based upon sequence from: Human
Host: QP7910 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) UFD1L, homolog, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7910.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Pro307
Amino Acid Sequence: MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP ERQVQHEEST EGEADHSGYA GELGFRAFSG SGNRLDGKKK GVEPSPSPIK PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF VAFSGEGQSL RKKGRKP
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human UFD1L, homolog Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human UFD1L, homolog Protein General Information | |
|---|---|
| Alternate Names | |
| UFD1; Ubiquitin fusion degradation protein 1 homol | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | UFD1L |
| Entrez Gene ID | 7353 |
| Ensemble Gene ID | ENSG00000070010 |
| RefSeq Protein Accession(s) | NP_001030324.2 |
| RefSeq mRNA Accession(s) | NM_001035247.2, NM_005659.6 |
| UniProt ID(s) | Q92890 |
| UniGene ID(s) | Hs.474213 |
| HGNC ID(s) | HGNC:12520 |
| COSMIC ID Link(s) | UFD1L |
| KEGG Gene ID(s) | hsa:7353 |
| PharmGKB ID(s) | PA37167 |
| General Description of Recombinant Human UFD1L, homolog Protein. | |
| Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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