PDF DatasheetHuman Cell death activator CIDE-3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cell death activator CIDE-3 based upon sequence from: Human
Host: QP7912 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cell death activator CIDE-3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7912.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MEYAMKSLSL LYPKSLSRHV SVRTSVVTQQ LLSEPSPKAP RARPCRVSTA DRSVRKGIMA YSLEDLLLKV RDTLMLADKP FFLVLEEDGT TVETEEYFQA LAGDTVFMVL QKGQKWQPPS EQGTRHPLSL SHKPAKKIDV ARVTFDLYKL NPQDFIGCLN VKATFYDTYS LSYDLHCCGA KRIMKEAFRW ALFSMQATGH VLLGTSCYLQ QLLDATEEGQ PPKGKASSLI PTCLKILQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Cell death activator CIDE-3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Cell death activator CIDE-3 Protein General Information | |
|---|---|
| Alternate Names | |
| CIDE-3; FPLD5; FSP27; CIDE3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CIDEC |
| Entrez Gene ID | 63924 |
| Ensemble Gene ID | ENSG00000187288 |
| RefSeq Protein Accession(s) | NP_001186480.1 |
| RefSeq mRNA Accession(s) | NM_001199551.1, NM_001199552.1, NM_001199623.1, NM_001321142.1, NM_001321143.1, NM_001321144.1, NM_022094.3 |
| UniProt ID(s) | Q96AQ7 |
| UniGene ID(s) | Hs.567562 |
| HGNC ID(s) | HGNC:24229 |
| COSMIC ID Link(s) | CIDEC |
| KEGG Gene ID(s) | hsa:63924 |
| PharmGKB ID(s) | PA134923736 |
| General Description of Recombinant Human Cell death activator CIDE-3 Protein. | |
| Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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