PDF DatasheetHuman Retinol dehydrogenase 12 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Retinol dehydrogenase 12 based upon sequence from: Human
Host: QP7917 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Retinol dehydrogenase 12, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7917.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Glu316
Amino Acid Sequence: MLVTLGLLTS FFSFLYMVAP SIRKFFAGGV CRTNVQLPGK VVVITGANTG IGKETARELA SRGARVYIAC RDVLKGESAA SEIRVDTKNS QVLVRKLDLS DTKSIRAFAE GFLAEEKQLH ILINNAGVMM CPYSKTADGF ETHLGVNHLG HFLLTYLLLE RLKVSAPARV VNVSSVAHHI GKIPFHDLQS EKRYSRGFAY CHSKLANVLF TRELAKRLQG TGVTTYAVHP GVVRSELVRH SSLLCLLWRL FSPFVKTARE GAQTSLHCAL AEGLEPLSGK YFSDCKRTWV SPRARNNKTA ERLWNVSCEL LGIRWE
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Retinol dehydrogenase 12 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Retinol dehydrogenase 12 Protein General Information | |
|---|---|
| Alternate Names | |
| LCA13; RP53; SDR7C2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RDH12 |
| Entrez Gene ID | 145226 |
| Ensemble Gene ID | ENSG00000139988 |
| RefSeq Protein Accession(s) | NP_689656.2 |
| RefSeq mRNA Accession(s) | NM_152443.2 |
| UniProt ID(s) | Q96NR8 |
| UniGene ID(s) | Hs.415322 |
| HGNC ID(s) | HGNC:19977 |
| COSMIC ID Link(s) | RDH12 |
| KEGG Gene ID(s) | hsa:145226 |
| PharmGKB ID(s) | PA134864793 |
| General Description of Recombinant Human Retinol dehydrogenase 12 Protein. | |
| Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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