PDF DatasheetHuman Protein quaking Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein quaking based upon sequence from: Human
Host: QP7918 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein quaking, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7918.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn341
Amino Acid Sequence: MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein quaking Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein quaking Protein General Information | |
|---|---|
| Alternate Names | |
| Hqk; QK; QK3; hqkI; QK1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | QKI |
| Entrez Gene ID | 9444 |
| Ensemble Gene ID | ENSG00000112531 |
| RefSeq Protein Accession(s) | NP_001288014.1 |
| RefSeq mRNA Accession(s) | NM_001301085.1, NM_006775.2, NM_206853.2, NM_206854.2, NM_206855.2, XM_011536259.2 |
| UniProt ID(s) | Q96PU8 |
| UniGene ID(s) | Hs.510324 |
| HGNC ID(s) | HGNC:21100 |
| COSMIC ID Link(s) | QKI |
| KEGG Gene ID(s) | hsa:9444 |
| PharmGKB ID(s) | PA134912180 |
| General Description of Recombinant Human Protein quaking Protein. | |
| RNA-binding protein that plays a central role in myelinization. Binds to the 5′-NACUAAY-N(1,20)-UAAY-3′ RNA core sequence. Regulates target mRNA stability. In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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