PDF DatasheetHuman SARAF Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SARAF based upon sequence from: Human
Host: QP7982 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SARAF, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7982.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Ser195 – Arg339
Amino Acid Sequence: SDGQYSPPPY SEYPPFSHRY QRFTNSAGPP PPGFKSEFTG PQNTGHGATS GFGSAFTGQQ GYENSGPGFW TGLGTGGILG YLFGSNRAAT PFSDSWYYPS YPPSYPGTWN RAYSPLHGGS GSYSVCSNSD TKTRTASGYG GTRRR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human SARAF Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SARAF Protein General Information | |
|---|---|
| Alternate Names | |
| TMEM66; FOAP-7; XTP3; HSPC035; Store-operated calcium entry-associated regulatory fact | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SARAF |
| Entrez Gene ID | 51669 |
| Ensemble Gene ID | ENSG00000133872 |
| RefSeq Protein Accession(s) | NP_001271168.1 |
| RefSeq mRNA Accession(s) | NM_001284239.1, NM_016127.5 |
| UniProt ID(s) | Q96BY9 |
| UniGene ID(s) | Hs.521487 |
| HGNC ID(s) | HGNC:28789 |
| KEGG Gene ID(s) | hsa:51669 |
| PharmGKB ID(s) | PA142670779 |
| General Description of Recombinant Human SARAF Protein. | |
| Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. In response to cytosolic Ca2+ elevation after endoplasmic reticulum Ca2+ refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca2+ levels, and thus preventing the overload of the cell with excessive Ca2+ ions. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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