PDF DatasheetHuman NAD-dependent protein deacetylase sirtuin-6 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NAD-dependent protein deacetylase sirtuin-6 based upon sequence from: Human
Host: QP7987 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NAD-dependent protein deacetylase sirtuin-6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7987.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: SVNYAAGLSP YADKGKCGLP EIFDPPEELE RKVWELARLV WQSSSVVFHT GAGISTASGI PDFRGPHGVW TMEERGLAPK FDTTFESARP TQTHMALVQL ERVGLLRFLV SQNVDGLHVR SGFPRDKLAE LHGNMFVEEC AKCKTQYVRD TVVGTMGLKA TGRLCTVAKA RGLRACRGEL RDTILDWEDS LPDRDLALAD EASRNADLSI TLGTSLQIRP SGNLPLATKR RGGRLVIVNL QPTKHDRHAD LRIHGYVDEV MTRLMKHLGL EIPAWDGPRV LERALPPLPR PPTPKLEPKE ESPTRINGSI PAGPKQEPCA QHNGSEPASP KRERPTSPAP HRPPKRVKAK AVPS
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NAD-dependent protein deacetylase sirtuin-6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NAD-dependent protein deacetylase sirtuin-6 Protein General Information | |
|---|---|
| Alternate Names | |
| SIR2L6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SIRT6 |
| Entrez Gene ID | 51548 |
| Ensemble Gene ID | ENSG00000077463 |
| RefSeq Protein Accession(s) | NP_001180214.1 |
| RefSeq mRNA Accession(s) | NM_001193285.2, NM_001321058.1, NM_001321059.1, NM_001321060.1, NM_001321061.1, NM_001321062.1, NM_001321063.1, NM_001321064.1, NM_016539.3 |
| UniProt ID(s) | Q8N6T7 |
| UniGene ID(s) | Hs.423756 |
| HGNC ID(s) | HGNC:14934 |
| COSMIC ID Link(s) | SIRT6 |
| KEGG Gene ID(s) | hsa:51548 |
| PharmGKB ID(s) | PA37939 |
| General Description of Recombinant Human NAD-dependent protein deacetylase sirtuin-6 Protein. | |
| NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.