PDF DatasheetHuman E3 ubiquitin-protein ligase TRIM11 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase TRIM11 based upon sequence from: Human
Host: QP8004 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase TRIM11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8004.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met267 – Gln468
Amino Acid Sequence: MELRTVCRVP GLVETLRRFR GDVTLDPDTA NPELILSEDR RSVQRGDLRQ ALPDSPERFD PGPCVLGQER FTSGRHYWEV EVGDRTSWAL GVCRENVNRK EKGELSAGNG FWILVFLGSY YNSSERALAP LRDPPRRVGI FLDYEAGHLS FYSATDGSLL FIFPEIPFSG TLRPLFSPLS SSPTPMTICR PKGGSGDTLA PQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human E3 ubiquitin-protein ligase TRIM11 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human E3 ubiquitin-protein ligase TRIM11 Protein General Information | |
|---|---|
| Alternate Names | |
| RNF92; BIA1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TRIM11 |
| Entrez Gene ID | 81559 |
| Ensemble Gene ID | ENSG00000154370 |
| RefSeq Protein Accession(s) | NP_660215.1 |
| RefSeq mRNA Accession(s) | NM_145214.2, XM_017002412.1 |
| UniProt ID(s) | Q96F44 |
| UniGene ID(s) | Hs.13543 |
| HGNC ID(s) | HGNC:16281 |
| COSMIC ID Link(s) | TRIM11 |
| KEGG Gene ID(s) | hsa:81559 |
| PharmGKB ID(s) | PA38112 |
| General Description of Recombinant Human E3 ubiquitin-protein ligase TRIM11 Protein. | |
| E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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