PDF DatasheetHuman PNKP Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PNKP based upon sequence from: Human
Host: QP8008 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PNKP, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8008.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gly521
Amino Acid Sequence: MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANDGTPIS IGDSIFVGDA AGRPANWAPG RKKKDFSCAD RLFALNLGLP FATPEEFFLK WPAAGFELPA FDPRTVSRSG PLCLPESRAL LSASPEVVVA VGFPGAGKST FLKKHLVSAG YVHVNRDTLG SWQRCVTTCE TALKQGKRVA IDNTNPDAAS RARYVQCARA AGVPCRCFLF TATLEQARHN NRFREMTDSS HIPVSDMVMY GYRKQFEAPT LAEGFSAILE IPFRLWVEPR LGRLYCQFSE G
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PNKP Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PNKP Protein General Information | |
|---|---|
| Alternate Names | |
| EIEE10; MCSZ; AOA4; PNK; Bifunctional polynucleotide phosphatase/kina | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PNKP |
| Entrez Gene ID | 11284 |
| Ensemble Gene ID | ENSG00000039650 |
| RefSeq Protein Accession(s) | NP_009185.2 |
| RefSeq mRNA Accession(s) | NM_007254.3 |
| UniProt ID(s) | Q96T60 |
| UniGene ID(s) | Hs.78016 |
| HGNC ID(s) | HGNC:9154 |
| COSMIC ID Link(s) | PNKP |
| KEGG Gene ID(s) | hsa:11284 |
| PharmGKB ID(s) | PA33477 |
| General Description of Recombinant Human PNKP Protein. | |
| Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either roving 3′-phosphates from, or by phosphorylating 5′-hydroxyl groups on, the ribose sugar of the DNA backbone. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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