PDF DatasheetS. aureus Staphylococcal complement inhibitor Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Staphylococcal complement inhibitor based upon sequence from: S. aureus
Host: QP8018 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Staphylococcus aureus (strain N315) Staphylococcal complement inhibitor, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8018.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser32 – Tyr116
Amino Acid Sequence: STSLPTSNEY QNEKLANELK SLLDELNVNE LATGSLNTYY KRTIKISGLK AMYALKSKDF KKMSEAKYQL QKIYNEIDEA LKSKY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of S. aureus Staphylococcal complement inhibitor Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant S. aureus Staphylococcal complement inhibitor Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | scn |
| RefSeq Protein Accession(s) | WP_000702262.1 |
| RefSeq mRNA Accession(s) | NC_002745.2 |
| UniProt ID(s) | Q99SU9 |
| KEGG Gene ID(s) | sau:SA1754 |
| General Description of Recombinant S. aureus Staphylococcal complement inhibitor Protein. | |
| Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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