PDF DatasheetHuman Methylosome protein 50 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Methylosome protein 50 based upon sequence from: Human
Host: QP8020 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Methylosome protein 50, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8020.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Leu312
Amino Acid Sequence: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV RDATWSPLNH SL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Methylosome protein 50 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Methylosome protein 50 Protein General Information | |
|---|---|
| Alternate Names | |
| p44/Mep50; MEP50; Nbla10071; HKMT1069; MEP-50; p44 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | WDR77 |
| Entrez Gene ID | 79084 |
| Ensemble Gene ID | ENSG00000116455 |
| RefSeq Protein Accession(s) | NP_001303991.1 |
| RefSeq mRNA Accession(s) | NM_001317062.1, NM_001317063.1, NM_001317064.1, NM_024102.3 |
| UniProt ID(s) | Q9BQA1 |
| UniGene ID(s) | Hs.204773 |
| HGNC ID(s) | HGNC:29652 |
| COSMIC ID Link(s) | WDR77 |
| KEGG Gene ID(s) | hsa:79084 |
| PharmGKB ID(s) | PA142670581 |
| General Description of Recombinant Human Methylosome protein 50 Protein. | |
| Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assbly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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