PDF DatasheetHuman Prohibitin-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Prohibitin-2 based upon sequence from: Human
Host: QP8027 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Prohibitin-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8027.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: AQNLKDLAGR LPAGPRGMGT ALKLLLGAGA VAYGVRESVF TVEGGHRAIF FNRIGGVQQD TILAEGLHFR IPWFQYPIIY DIRARPRKIS SPTGSKDLQM VNISLRVLSR PNAQELPSMY QRLGLDYEER VLPSIVNEVL KSVVAKFNAS QLITQRAQVS LLIRRELTER AKDFSLILDD VAITELSFSR EYTAAVEAKQ VAQQEAQRAQ FLVEKAKQEQ RQKIVQAEGE AEAAKMLGEA LSKNPGYIKL RKIRAAQNIS KTIATSQNRI YLTADNLVLN LQDESFTRGS DSLIKGKK
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Prohibitin-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Prohibitin-2 Protein General Information | |
|---|---|
| Alternate Names | |
| PNAS-141; p22; BAP; BCAP37; Bap37; REA; hBAP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PHB2 |
| Entrez Gene ID | 11331 |
| Ensemble Gene ID | ENSG00000215021 |
| RefSeq Protein Accession(s) | NP_001138303.1 |
| RefSeq mRNA Accession(s) | NM_001144831.1, NM_001267700.1 |
| UniProt ID(s) | Q99623 |
| UniGene ID(s) | Hs.504620 |
| HGNC ID(s) | HGNC:30306 |
| COSMIC ID Link(s) | PHB2 |
| KEGG Gene ID(s) | hsa:11331 |
| PharmGKB ID(s) | PA142671181 |
| General Description of Recombinant Human Prohibitin-2 Protein. | |
| Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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