PDF DatasheetHuman CPEB1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CPEB1 based upon sequence from: Human
Isoform: Isoform 4
Host: QP8045 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CPEB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8045.
Bioactivity Data: Untested
Full Length? Full Length of isoform 4
Expression Region: Met1 – Ser486
Amino Acid Sequence: MLFPTSAQES SRGLPDANDL CLGLQSLSLT GWDRPWSTQD SDSSAQSSTH SVLSMLHNPL GNVLGKPPLS FLPLDPLGSD LVDKFPAPSV RGSRLDTRPI LDSRSSSPSD SDTSGFSSGS DHLSDLISSL RISPPLPFLS LSGGGPRDPL KMGVGSRMDQ EQAALAAVTP SPTSASKRWP GASVWPSWDL LEAPKDPFSI EREARLHRQA AAVNEATCTW SGQLPPRNYK NPIYSCKVFL GGVPWDITEA GLVNTFRVFG SLSVEWPGKD GKHPRCPPKG YVYLVFELEK SVRSLLQACS HDPLSPDGLS EYYFKMSSRR MRCKEVQVIP WVLADSNFVR SPSQRLDPSR TVFVGALHGM LNAEALAAIL NDLFGGVVYA GIDTDKHKYP IGSGRVTFNN QRSYLKAVSA AFVEIKTTKF TKKVQIDPYL EDSLCHICSS QPGPFFCRDQ VCFKYFCRSC WHWRHSMEGL RHHSPLMRNQ KNRDSS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CPEB1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CPEB1 Protein General Information | |
|---|---|
| Alternate Names | |
| CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1; Cytoplasmic polyadenylation element-binding protein | |
| Molecular Weight | |
| Isoform 4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CPEB1 |
| Entrez Gene ID | 64506 |
| Ensemble Gene ID | ENSG00000214575 |
| RefSeq Protein Accession(s) | NP_001073001.1 |
| RefSeq mRNA Accession(s) | NM_001079533.1, NM_001079534.1, NM_001079535.1, NM_001288819.1, NM_030594.4 |
| UniProt ID(s) | Q9BZB8 |
| UniGene ID(s) | Hs.459132 |
| HGNC ID(s) | HGNC:21744 |
| KEGG Gene ID(s) | hsa:64506 |
| PharmGKB ID(s) | PA134929879 |
| General Description of Recombinant Human CPEB1 Protein. | |
| Sequence-specific RNA-binding protein that regulates mRNA Cytoplasmic domain polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the Cytoplasmic domain polyadenylation elent (CPE), an uridine-rich sequence elent (consensus sequence 5′-UUUUUAU-3′) within the mRNA 3′-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation . Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation . Induces the assbly of stress granules in the absence of stress. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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