PDF DatasheetHuman Gem-associated protein 7 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Gem-associated protein 7 based upon sequence from: Human
Host: QP8052 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Gem-associated protein 7, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8052.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Pro131
Amino Acid Sequence: MQTPVNIPVP VLRLPRGPDG FSRGFAPDGR RAPLRPEVPE IQECPIAQES LESQEQRARA ALRERYLRSL LAMVGHQVSF TLHEGVRVAA HFGATDLDVA NFYVSQLQTP IGVQAEALLR CSDIISYTFK P
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Gem-associated protein 7 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Gem-associated protein 7 Protein General Information | |
|---|---|
| Alternate Names | |
| SIP3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GEMIN7 |
| Entrez Gene ID | 79760 |
| Ensemble Gene ID | ENSG00000142252 |
| RefSeq Protein Accession(s) | NP_001007270.1 |
| RefSeq mRNA Accession(s) | NM_001007269.1, NM_001007270.1, NM_001319054.1, NM_001319055.1, NM_024707.2, XM_005259262.3, XM_005259263.4, XM_017027312.1 |
| UniProt ID(s) | Q9H840 |
| UniGene ID(s) | Hs.466919 |
| HGNC ID(s) | HGNC:20045 |
| COSMIC ID Link(s) | GEMIN7 |
| KEGG Gene ID(s) | hsa:79760 |
| PharmGKB ID(s) | PA134959810 |
| General Description of Recombinant Human Gem-associated protein 7 Protein. | |
| The SMN complex plays a catalyst role in the assbly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assbly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assbly of core snRNPs and their transport to the nucleus. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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