PDF DatasheetMouse Interleukin-23 subunit alpha Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Interleukin-23 subunit alpha based upon sequence from: Mouse
Host: QP8064 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Interleukin-23 subunit alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8064.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val22 – Ala1
Amino Acid Sequence: VPRSSSPDWA QCQQLSRNLC MLAWNAHAPA GHMNLLREEE DEETKNNVPR IQCEDGCDPQ GLKDNSQFCL QRIRQGLAFY KHLLDSDIFK GEPALLPDSP MEQLHTSLLG LSQLLQPEDH PRETQQMPSL SSSQQWQRPL LRSKILRSLQ AFLAIAARVF AHGAATLTEP LVPTA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Interleukin-23 subunit alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Interleukin-23 subunit alpha Protein General Information | |
|---|---|
| Alternate Names | |
| IL-23; p19 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Il23a |
| Entrez Gene ID | 83430 |
| Ensemble Gene ID | ENSMUSG00000025383 |
| RefSeq Protein Accession(s) | NP_112542.1 |
| RefSeq mRNA Accession(s) | NM_031252.2 |
| UniProt ID(s) | Q9EQ14 |
| UniGene ID(s) | Mm.125482 |
| COSMIC ID Link(s) | Il23a |
| KEGG Gene ID(s) | mmu:83430 |
| General Description of Recombinant Mouse Interleukin-23 subunit alpha Protein. | |
| Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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