PDF DatasheetHuman Ras-related protein Rab-17 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ras-related protein Rab-17 based upon sequence from: Human
Host: QP8065 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ras-related protein Rab-17, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8065.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – His212
Amino Acid Sequence: MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF ADSQKLLFME TSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN KGPARQAKCC AH
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Ras-related protein Rab-17 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ras-related protein Rab-17 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAB17 |
| Entrez Gene ID | 64284 |
| Ensemble Gene ID | ENSG00000124839 |
| RefSeq Protein Accession(s) | NP_071894.1 |
| RefSeq mRNA Accession(s) | NM_022449.3 |
| UniProt ID(s) | Q9H0T7 |
| UniGene ID(s) | Hs.44278 |
| HGNC ID(s) | HGNC:16523 |
| COSMIC ID Link(s) | RAB17 |
| KEGG Gene ID(s) | hsa:64284 |
| PharmGKB ID(s) | PA34105 |
| General Description of Recombinant Human Ras-related protein Rab-17 Protein. | |
| The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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