PDF DatasheetHuman Exonuclease V Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Exonuclease V based upon sequence from: Human
Host: QP8066 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Exonuclease V, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8066.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys373
Amino Acid Sequence: MAETREEETV SAEASGFSDL SDSEFLEFLD LEDAQESKAL VNMPGPSSES LGKDDKPISL QNWKRGLDIL SPMERFHLKY LYVTDLATQN WCELQTAYGK ELPGFLAPEK AAVLDTGASI HLARELELHD LVTVPVTTKE DAWAIKFLNI LLLIPTLQSE GHIREFPVFG EGEGVLLVGV IDELHYTAKG ELELAELKTR RRPMLPLEAQ KKKDCFQVSL YKYIFDAMVQ GKVTPASLIH HTKLCLEKPL GPSVLRHAQQ GGFSVKSLGD LMELVFLSLT LSDLPVIDIL KIEYIHQETA TVLGTEIVAF KEKEVRAKVQ HYMAYWMGHR EPQGVDVEEA WKCRTCTYAD ICEWRKGSGV LSSTLAPQVK KAK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Exonuclease V Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Exonuclease V Protein General Information | |
|---|---|
| Alternate Names | |
| DEM1; Exo V; hExo5; C1orf176 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EXO5 |
| Entrez Gene ID | 64789 |
| Ensemble Gene ID | ENSG00000164002 |
| RefSeq Protein Accession(s) | NP_001333875.1 |
| RefSeq mRNA Accession(s) | NM_001346946.1, NM_001346947.1, NM_001346948.1, NM_001346949.1, NM_001346950.1, NM_001346951.1, NM_001346952.1, NM_001346953.1, NM_001346954.1, NM_001346955.1, NM_001346956.1, NM_022774.2, XM_017002099.1, XM_017002102.1 |
| UniProt ID(s) | Q9H790 |
| UniGene ID(s) | Hs.59584 |
| HGNC ID(s) | HGNC:26115 |
| KEGG Gene ID(s) | hsa:64789 |
| PharmGKB ID(s) | PA164718736 |
| General Description of Recombinant Human Exonuclease V Protein. | |
| Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5′-3′ and 3′-5′ exonuclease activities with a strong preference for 5′-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3′-5′ exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5′-directionality activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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