PDF DatasheetHuman NMNAT1 / NMNAT Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NMNAT1 / NMNAT based upon sequence from: Human
Host: QP8070 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NMNAT1 / NMNAT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8070.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Thr279
Amino Acid Sequence: MENSEKTEVV LLACGSFNPI TNMHLRLFEL AKDYMNGTGR YTVVKGIISP VGDAYKKKGL IPAYHRVIMA ELATKNSKWV EVDTWESLQK EWKETLKVLR HHQEKLEASD CDHQQNSPTL ERPGRKRKWT ETQDSSQKKS LEPKTKAVPK VKLLCGADLL ESFAVPNLWK SEDITQIVAN YGLICVTRAG NDAQKFIYES DVLWKHRSNI HVVNEWIAND ISSTKIRRAL RRGQSIRYLV PDLVQEYIEK HNLYSSESED RNAGVILAPL QRNTAEAKT
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human NMNAT1 / NMNAT Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NMNAT1 / NMNAT Protein General Information | |
|---|---|
| Alternate Names | |
| NMNAT1; NMNAT; PNAT1; LCA9; NMNAT | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NMNAT1 |
| Entrez Gene ID | 64802 |
| Ensemble Gene ID | ENSG00000173614 |
| RefSeq Protein Accession(s) | NP_001284707.1 |
| RefSeq mRNA Accession(s) | NM_001297778.1, NM_022787.3, XM_017002107.1 |
| UniProt ID(s) | Q9HAN9 |
| UniGene ID(s) | Hs.633762 |
| HGNC ID(s) | HGNC:17877 |
| COSMIC ID Link(s) | NMNAT1 |
| KEGG Gene ID(s) | hsa:64802 |
| PharmGKB ID(s) | PA31660 |
| General Description of Recombinant Human NMNAT1 / NMNAT Protein. | |
| Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, prefers NAD+ and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+. Protects against axonal degeneration following mechanical or toxic insults | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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