PDF DatasheetHuman GNL3L Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant GNL3L based upon sequence from: Human
Host: QP8075 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) GNL3L, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8075.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asp582
Amino Acid Sequence: MMKLRHKNKK PGEGSKGHKK ISWPYPQPAK QNGKKATSKV PSAPHFVHPN DHANREAELK KKWVEEMREK QQAAREQERQ KRRTIESYCQ DVLRRQEEFE HKEEVLQELN MFPQLDDEAT RKAYYKEFRK VVEYSDVILE VLDARDPLGC RCFQMEEAVL RAQGNKKLVL VLNKIDLVPK EVVEKWLDYL RNELPTVAFK ASTQHQVKNL NRCSVPVDQA SESLLKSKAC FGAENLMRVL GNYCRLGEVR THIRVGVVGL PNVGKSSLIN SLKRSRACSV GAVPGITKFM QEVYLDKFIR LLDAPGIVPG PNSEVGTILR NCVHVQKLAD PVTPVETILQ RCNLEEISNY YGVSGFQTTE HFLTAVAHRL GKKKKGGLYS QEQAAKAVLA DWVSGKISFY IPPPATHTLP THLSAEIVKE MTEVFDIEDT EQANEDTMEC LATGESDELL GDTDPLEMEI KLLHSPMTKI ADAIENKTTV YKIGDLTGYC TNPNRHQMGW AKRNVDHRPK SNSMVDVCSV DRRSVLQRIM ETDPLQQGQA LASALKNKKK MQKRADKIAS KLSDSMMSAL DLSGNADDGV GD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GNL3L Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human GNL3L Protein General Information | |
|---|---|
| Alternate Names | |
| GNL3B; Guanine nucleotide-binding protein-like 3-like prote | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GNL3L |
| Entrez Gene ID | 54552 |
| Ensemble Gene ID | ENSG00000130119 |
| RefSeq Protein Accession(s) | NP_001171748.1 |
| RefSeq mRNA Accession(s) | NM_001184819.1, NM_019067.5 |
| UniProt ID(s) | Q9NVN8 |
| UniGene ID(s) | Hs.654677 |
| HGNC ID(s) | HGNC:25553 |
| COSMIC ID Link(s) | GNL3L |
| KEGG Gene ID(s) | hsa:54552 |
| PharmGKB ID(s) | PA134922876 |
| General Description of Recombinant Human GNL3L Protein. | |
| Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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