PDF DatasheetHuman Dickkopf-related protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Dickkopf-related protein 2 based upon sequence from: Human
Host: QP8081 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Dickkopf-related protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8081.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Lys34 – Ile259
Amino Acid Sequence: KLNSIKSSLG GETPGQAANR SAGMYQGLAF GGSKKGKNLG QAYPCSSDKE CEVGRYCHSP HQGSSACMVC RRKKKRCHRD GMCCPSTRCN NGICIPVTES ILTPHIPALD GTRHRDRNHG HYSNHDLGWQ NLGRPHTKMS HIKGHEGDPC LRSSDCIEGF CCARHFWTKI CKPVLHQGEV CTKQRKKGSH GLEIFQRCDC AKGLSCKVWK DATYSSKARL HVCQKI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Dickkopf-related protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Dickkopf-related protein 2 Protein General Information | |
|---|---|
| Alternate Names | |
| DKK-2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DKK2 |
| Entrez Gene ID | 27123 |
| Ensemble Gene ID | ENSG00000155011 |
| RefSeq Protein Accession(s) | NP_055236.1 |
| RefSeq mRNA Accession(s) | NM_014421.2 |
| UniProt ID(s) | Q9UBU2 |
| UniGene ID(s) | Hs.211869 |
| HGNC ID(s) | HGNC:2892 |
| COSMIC ID Link(s) | DKK2 |
| KEGG Gene ID(s) | hsa:27123 |
| PharmGKB ID(s) | PA27346 |
| General Description of Recombinant Human Dickkopf-related protein 2 Protein. | |
| Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmbrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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