PDF DatasheetHuman BPI fold-containing family A member 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant BPI fold-containing family A member 1 based upon sequence from: Human
Host: QP8090 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) BPI fold-containing family A member 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8090.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gln20 – Val2
Amino Acid Sequence: QFGGLPVPLD QTLPLNVNPA LPLSPTGLAG SLTNALSNGL LSGGLLGILE NLPLLDILKP GGGTSGGLLG GLLGKVTSVI PGLNNIIDIK VTDPQLLELG LVQSPDGHRL YVTIPLGIKL QVNTPLVGAS LLRLAVKLDI TAEILAVRDK QERIHLVLGD CTHSPGSLQI SLLDGLGPLP IQGLLDSLTG ILNKVLPELV QGNVCPLVNE VLRGLDITLV HDIVNMLIHG LQFVIKV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human BPI fold-containing family A member 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human BPI fold-containing family A member 1 Protein General Information | |
|---|---|
| Alternate Names | |
| SPLUNC1; SPURT; NASG; PLUNC; bA49G10.5; LUNX | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BPIFA1 |
| Entrez Gene ID | 51297 |
| Ensemble Gene ID | ENSG00000198183 |
| RefSeq Protein Accession(s) | NP_001230122.1 |
| RefSeq mRNA Accession(s) | NM_001243193.1, NM_016583.3, NM_130852.2 |
| UniProt ID(s) | Q9NP55 |
| UniGene ID(s) | Hs.211092 |
| HGNC ID(s) | HGNC:15749 |
| KEGG Gene ID(s) | hsa:51297 |
| PharmGKB ID(s) | PA33423 |
| General Description of Recombinant Human BPI fold-containing family A member 1 Protein. | |
| Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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