PDF DatasheetHuman CCR4-NOT transcription complex subunit 8 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CCR4-NOT transcription complex subunit 8 based upon sequence from: Human
Host: QP8105 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CCR4-NOT transcription complex subunit 8, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8105.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln292
Amino Acid Sequence: MPAALVENSQ VICEVWASNL EEEMRKIREI VLSYSYIAMD TEFPGVVVRP IGEFRSSIDY QYQLLRCNVD LLKIIQLGLT FTNEKGEYPS GINTWQFNFK FNLTEDMYSQ DSIDLLANSG LQFQKHEEEG IDTLHFAELL MTSGVVLCDN VKWLSFHSGY DFGYMVKLLT DSRLPEEEHE FFHILNLFFP SIYDVKYLMK SCKNLKGGLQ EVADQLDLQR IGRQHQAGSD SLLTGMAFFR MKELFFEDSI DDAKYCGRLY GLGTGVAQKQ NEDVDSAQEK MSILAIINNM QQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CCR4-NOT transcription complex subunit 8 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CCR4-NOT transcription complex subunit 8 Protein General Information | |
|---|---|
| Alternate Names | |
| Caf1b; CALIF; hCAF1; POP2; CAF1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CNOT8 |
| Entrez Gene ID | 9337 |
| Ensemble Gene ID | ENSG00000155508 |
| RefSeq Protein Accession(s) | NP_001288002.1 |
| RefSeq mRNA Accession(s) | NM_001301073.1, NM_001301074.1, NM_001301075.1, NM_001301077.1, NM_001301080.1, NM_001301082.1, NM_001301083.1, NM_001301086.1, NM_004779.5, XM_005268527.2, XM_011537706.1, XM_011537708.2, XM_017010048.1, XM_017010049.1, XM_017010050.1, XM_017010051.1, XM_017010052.1, XM_017010053.1, XM_017010054.1, XM_017010055.1, XM_017010056.1, XM_017010057.1 |
| UniProt ID(s) | Q9UFF9 |
| UniGene ID(s) | Hs.26703 |
| HGNC ID(s) | HGNC:9207 |
| COSMIC ID Link(s) | CNOT8 |
| KEGG Gene ID(s) | hsa:9337 |
| PharmGKB ID(s) | PA26679 |
| General Description of Recombinant Human CCR4-NOT transcription complex subunit 8 Protein. | |
| Has 3′-5′ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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